Feeder layer
The inner surface of the culture dish.
Mouse embryonic skin cells that have
been treated so they will not divide.
A sticky surface to which they can attach.
Release nutrients into the culture medium.
Leukemic inhibitory factor (LIF)
How
Undifferentiated to differentiated cell
And
Genes on and off
Can control
Abnormal
Cell
Stem cell calssification
1. Based upon location
Embryonic stem cells
Somatic/ adult stem cells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
Mid-1800s - Beginning research of Embryo
1908 – ‘Stem Cell’ from Alexander Maksimov
1963 – Self reproducing cell
1978 – Found Blood stem cell
1981 - Embryonic stem cell
1998 - Human's embryonic stem cell
2001 – First human embryo cloning
(중략)
2.1 Adult Stem Cell - How?From Bone Marrow
HSCs and MSCs are rich in b
유전질환이란,
비정상적인 유전자나 염색체에 의해 일어나는 질병으로서, 특히 선천적으로 나타나는 질환의 경우가 많다. 대부분의 유전질환은 드물게 일어나 수천 혹은 수백만의 사람들 중 오직 한 사람에서만 나타난다. 유전질환은 유전이 될 수도 있고 그렇지 않을 수도 있다. 유전 질환 주에는
1908 - The term "stem cell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stem cells.
1998 - James Thomson and coworkers derive the first human embryonic stem cell line at the University of Wisconsin–Madison.
2004–2005 - Korean researcher Hwan
A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp
1) 연구현황
① 의학적 가능성
성체 줄기세포는 존재가 모두 확인되지 않았고, 세포의 수가 많지 않아 분리하기가 쉽지 않으며, 나이가 들수록 조직에 존재하는 성체 줄기세포의 숫자, 분화능력 및 증식능력이 감소한다. 또한 유전적 및 대사성 질환이 있는 환자의 경우 환자 자신의 자가 성체 줄기